The actual fraction of eCLIP-overlapping TDP-43-INSCRIBE edit clusters (diamonds) compared to that of the 20 permuted clusters (box plot, n = 20). The actual fraction was plotted using the confident edit clusters derived from 3 INSCRIBE technical replicates. The box shows the quartiles while the whiskers extend to show the rest of the distribution; the median is represented by the center line. Z-scores: TDP-43-INSCRIBE, 15.61; Enzyme-only control, -0.46.