The actual fraction of UGCAUG-containing RBFOX2-INSCRIBE edit clusters/RBFOX2 eCLIP IDR peaks (dots) compared to the 20 permuted clusters (box plot, n = 20). Z-scores: RBFOX2-INSCRIBE, 49.93; Enzyme-only control, 0.43; RBFOX2-STAMP, 23.08; RBFOX2-eCLIP, 117.83. In ( e f ), the box shows the quartiles while the whiskers extend to show the rest of the distribution; the median is represented by the center line. Enrichment is defined as the ratio of actual fraction to the mean of the permuted-derived fractionThe actual fraction was plotted using the confident edit clusters derived from 3 INSCRIBE technical replicates.
