Microscopy from Scientific Research

Complex shear moduli of human brains measured by magnetic resonance elastography (MRE). Brain tissue of patients with Alzheimer's disease (AD) (B) is softer than that of age-matched healthy controls (A). Adapted from Gerischer et al.,189NeuroImage: Clinical, 18, Gerischer et al.,189with permission from Elsevier. Considering hippocampal stiffness in in addition to magnetic resonance imaging-based hippocampal volume and mean diffusivity significantly improved diagnostic sensitivity.189

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