Complex shear moduli of human brains measured by magnetic resonance elastography (MRE). Brain tissue of patients with Alzheimer's disease (AD) (B) is softer than that of age-matched healthy controls (A). Adapted from Gerischer et al.,189NeuroImage: Clinical, 18, Gerischer et al.,189with permission from Elsevier. Considering hippocampal stiffness in in addition to magnetic resonance imaging-based hippocampal volume and mean diffusivity significantly improved diagnostic sensitivity.189
