Pie Chart from Scientific Research

Functional profiles of spike-reactive CD4+T cells. (A–H) Data were generated with healthy-donor-derived PBMCs (n = 15) collected before the onset of the BA.2.86 variant. (B, C, E, F, and G) Each dot represents one donor, and lines depict the median. (B, E, and G) Friedman test followed by Dunn’s multiple comparisons test. (C and F) Kruskal-Wallis test followed by Dunn’s multiple comparisons test. (H) Polyfunctional responses were compared using a permutation test. p = 0.012 for Wu-Hu.1 f.s. vs. BA.1-Var, otherwise non-significant.****p < 0.0001, ***p < 0.001, **p < 0.01, and *p < 0.05.

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