Net frequencies (background subtracted using DMSO negative control) of CD4+ and CD8+ T cell responses to Wu-Hu.1 full spike and variant peptide pools as displayed in (B). (D and E) Each dot represents one donor, and lines depict the median. Healthy control (HC) ; chronic lymphocytic leukemia (CLL) . n = Kruskal-Wallis test followed by Dunns multiple comparisons test.*p < 0.05.