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Response of ET-1 on WT ETA and ETA mutants in ECL2. Data are presented as means SEM ( n = 4). All data were analyzed by one-way ANOVA by Dunnett’s multiple test compared with WT. * P < 0.05, ** P < 0.01, *** P < 0.001 and **** P < 0.0001 were considered statistically significant.
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