Bar Plot from Scientific Research

Effects of GLP-1R (top), GIPR (middle), and GCGR (bottom) mutations on retatrutide-induced cAMP accumulation. Bars represent differences in the calculated retatrutide potency (pEC 50 ) for representative mutants relative to the wild-type (WT). Data are colored according to the extent of effect. Data shown are from at least three independent experiments performed in quadruplicate. All data were analyzed by one-way ANOVA and Dunnett’s test. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001. N.D., values that could not be determined due to incomplete curve fits.

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