Illustration from Scientific Research

Amino acid sequence comparison of endogenous hormones, representative dual and triple agonists. Residues are colored according to sequence conservation among GLP-1, GIP and GCG. Aib -amino isobutyric acid, MeL -methyl L -leucine. Semaglutide, tirzepatide, peptide 20 (MAR423) and retatrutide are acylated with various fatty diacid moieties via a linker connected to the lysine residues at the positions of 20, 20, 10 and 17, respectively.

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