Workflow from Scientific Research

Schematic diagram of retatrutide recognition mode in GLP-1R, GIPR and GCGR, described by fingerprint strings encoding different interaction types of the surrounding residues in each receptor. Close-up views of the interactions are shown for the N-terminal nine residues of retatrutide. The polar contacts are shown as black dashed lines. Receptor residues are labeled with class B1 GPCR numbering and colored sky blue for salt bridge, red for hydrogen bond, orange for stacking and gray for hydrophobic interactions. Residues that show no interaction with retatrutide are displayed as white circles.

DOI