Illustration from Scientific Research

Sequence conservation of R15B414–639. The residues are colored according to ConSurf41conservation scores from cyan (variable) to burgundy (conserved). The consensus secondary structure, predicted using Jpred42and PsiPred,36is shown below the corresponding sequence. The secondary structural elements are denoted as follows: rectangle, helix; line, random coil. The substitutions of the residues targeted for mutagenesis are shown on the top with different mutants shown in different colors.

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