Polymersomes consist of biodegradable PEG-PDLLA block copolymers assembled into bilayered vesicles. Polymersome topology can be precisely controlled to form spheres and tubes of different sizes (SmS and LgS denote small and large spheres and SmT and LgT denote small and large tubes, respectively). Furthermore, polymersomes are labelled with radionuclides (89Zr), fluorescent dyes (BODIPY) or stable isotopes (157Gd).