Violin Plot from Scientific Research

CRISPR-induced editing of VHL was performed in HAP1 cells (day 0), and outcomes were quantified by NGS. Distributions of InDel scores, calculated as the log 2 ratio of day 13 frequency to day 6 frequency, show frameshifting, and in-frame InDels are strongly depleted in parental HAP1 (left) compared to HAP1–HIF1A–knockout (–KO) (right) (median InDel score -3.20 versus -0.20, respectively; Wilcoxon rank-sum two-sided P = 5.6 x 10 -18 ).

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