Cases with MSH6 F1088fs and/or MSH3 K383fs homopolymer frameshifts (in red), and cases without such mutations (in blue) ranked by mutation burden ( n = 217). Clonal alterations in MMR genes MLH1 , PMS2 , MSH2 and MSH6 , as well as subclonal MSH6 F1088fs and MSH3 K383fs frameshift status, are indicated below. Insets show MSH6 F1088fs and MSH3 K383fs mutation variant allele fraction. Extended Data Fig. 1a–c shows analysis restricted to BRAF V600E tumors.
