Microscopy from Scientific Research

Multiple-sequence alignment of exon 7 created by global alignment of BAP1 orthologs from eight species (gap open/extension penalty = 12/3); numbers are protein positions of human BAP1 (ENSP00000417132.1) and residues are colored by identity (black, 100%; dark gray, 80−100%; light gray, 60−80%; white, <60%). R179 (and the highly conserved H169 proton donor) is highlighted by a red arrow. Note that the glutamine residue in Drosophila aligns at human position R179, the only missense variant at this position tolerated in SGE.

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