Count abundance for variants that resulted in synonymous changes or edited intronic regions did not change significantly over a 21-day SGE screen (two-sided MannWhitneyWilcoxon test; D4 versus D21 counts, P = 0.3; NS, not significant), whereas variants resulting in stop-gained and frameshift consequences were significantly depleted (**** P < 2.2 x 10 - 16; n = 8,707 synonymous and intronic variants; n = 5,628 frameshift and stop-gained variants; mean z-score counts of three biological replicates at each time point). Boxes show the interquartile range, the horizontal lines show the median z-score count and whiskers show the maximum and minimum values that are not outliers.
