Workflow from Scientific Research

Proposed model for the effects of the ancient SVA F insertion and the recent SVA F 1 insertion on splicing patterns of ASIP transcripts. The original hominid ancestral allele—lacking either retrotransposon—splices normally between alternate noncoding exon 2 and coding exon 3. Insertion of the SVA F element then causes a fraction of ASIP transcripts to splice aberrantly to the introduced acceptor site, leading to early polyadenylation. The subsequent SVA F 1 insertion then restores normal splicing to coding exon 3 in all transcripts, possibly by sequestering the splice acceptor or splice enhancer motifs.

DOI