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Examples of Het FE variantsm.16,400 C>T ( c ) and m.7,496 T>C ( d ). Early clonal phylogenies, reconstructed using somatic nDNA mutations, are shown. Branch lengths are proportional to the number of somatic nDNA mutations. Clone-VAF in each clone, caVAF and blood-VAF are represented by bar plots at the bottom. Two pie charts in c and d indicate the proportions of mutant clones among clones of the individual (left) and among clones of other individuals (right).

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