Illustration from Scientific Research

Open access visualization of Illustration, Workflow, Cas13b-ADAR System, Guide RNA, mRNA
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DOI: 10.1038/s41587-024-02313-0

DOI

Schematic of the Cas13b-ADAR system. The DR motif-containing guide RNA (87 nt) binds its target mRNA (through 51 bp) to recruit the engineered PspCas13b-ADAR editase carrying a hyperactive ADAR2 E488Q deaminase domain.

#Illustration#Workflow#Cas13b-ADAR System#Guide RNA#mRNA#PspCas13b-ADAR Editase#ADAR2 E488Q Deaminase Domain

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