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Secondary structures of the two conformations of RORC RNA switch predicted by the RNAstructure algorithm 56 guided by the DMS reactivity data. The base pairing of Box 1 with either Box 3 (conformation 1) or Box 2 (conformation 2) is highlighted by a red frame. The two clusters were identified using the DRACO unsupervised deconvolution algorithm 28 .

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