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Schematic diagram of the neural loop for IOP sensing and feedback. Panel 1 depicts a neuroprosthetic contact lens that provides sensory feedback to the brain. Panel II is a schematic diagram of the neural reflex circuit for sensing IOP. Panel III records the stimulation signals to the somatosensory cortex and the corresponding potential signals collected in the motor cortex during abnormal intraocular pressure in rats. Panel IV shows a schematic diagram of sciatic nerve stimulation to induce contraction of the gastrocnemius muscle.

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