Comparison of the mean copy number values relative to tumour ploidy of Late N -to-Early T replicated genes (806 genes in BRCA and 656 genes in LUAD) in cancer cells versus bootstrapped late replicated genes in normal cells, and equivalently the comparison between Early N -to-Late T replicated genes (852 genes in BRCA and 387 genes in LUAD) in cancer cells versus bootstrapped early replicated genes in normal cells. The observed values are presented as diamonds while the bootstrapped results are shown as dots with error bars. The error bars represent the 95th percentile of the bootstrapped mean copy number values relative to tumour ploidy. In A , B , the annotated p -values represent the empirical p -values which were calculated by counting how many bootstrapped mean log2FC values of Late N+T genes were greater than the observed mean values of Late N -to-Early T genes divided by the total number of iterations, or equivalently, how many bootstrapped mean log2FC values of Early N+T genes were lower than the observed mean values of Early N -to-Late T genes divided by the total number of iterations.
