Scatter plot comparing the median difference in the exposure of mutational signatures in unaltered Late N+T and Early N+T replicated regions (x-axis) against the median difference of mutational signature exposures in altered Late N -to-Early T and Early N -to-Late T replicated regions (y-axis) in breast carcinoma (BRCA) tumours. Signatures located in the top right quadrant were found to be enriched in Late N+T and Early N -to-Late T replicated regions. Signatures located in the bottom left quadrant were found to be enriched in Early N+T and Late N -to-Early T replicated regions. The size of the points demonstrates the fraction of tumours in which the different mutational signatures have been found active.
