The number of APOBEC3 mutations per Mb in an omikli (top) and unclustered (bottom) context in cancer-associated genes localised at different unaltered RT and ART regions in BRCA tumours. Middle plot: the odds ratio is shown as dots and the 95% confidence intervals as vertical lines obtained by Fishers tests to investigate whether there was a significant enrichment of APOBEC3-mediated omikli mutations in cancer genes relative to unclustered APOBEC3 mutations in different unaltered RT and ART regions. Cancer-associated genes with Late N -to-Early T replication timing in BRCA are highlighted.
