Variance in BRCA mutation load explained by chromatin or replication timing signal in normal (HMEC) and tumour (MCF-7 or T47D). The bars represent the R 2 values derived from separate univariate linear models with mutation load as an independent variable and the chromatin signal or RT signal in normal or cancer cells as a dependent variable. Notably, RT in tumours can explain more of the variance in mutation load than the other factors.
