Mutation density (measured as the number of mutations relative to the size of the affected genomic regions) in gained, lost and copy number neutral genomic regions in 470 lung adenocarcinomas (LUAD). P-values reflect one-sided paired Wilcoxon tests. The centre line of the box plots represents the median value, the limits represent the 25th and 75th percentile, and the whiskers extend from the box to the largest and lowest value no further than 1.5 * IQR (interquartile range) away from the box.