Workflow from Scientific Research

Schematic illustrating the proposed mechanism that controls astrocyte glucose metabolism and provides metabolic support of neuronal activity. Potential sources of activity-dependent adenosine release are illustrated, including transporter-mediated release 19 , 22 , and extracellular breakdown of ATP 20 released at synapses 18 and by astrocytes 19 . -AR, -adrenoceptor; G6P, glucose-6-phosphate. In panels c , d , f , i , the numbers in parentheses indicate the numbers of animals per experimental group. P values were determined by one-way ANOVA followed by Sidak’s post-hoc test ( c , d , f ) or two-way ANOVA ( i ).

DOI