Time course (mean s.e.m.) ( g ) and summary data (individual values and mean s.e.m.) ( h ) of relative changes in the averaged fEPSP slope recorded in the CA1 area before and after induction of LTP by high-frequency Schaffer collateral fibre stimulation (HFS; 100 pulses at 100 Hz repeated 3 times with 60-s intervals) in hippocampal slices of Adora2b flox/flox mice transduced to express tdTomato in astrocytes (control), wild-type (WT) mice transduced to express iCre (control; n = 8/3), Adora2b flox/flox mice transduced to express iCre in astrocytes (A2BR-Astro-KD) and Adora2b flox/flox mice transduced to express iCre and in the presence of supplemental lactate or the -adrenoceptor agonist isoproterenol. In panels b , c , e , g , the numbers in parentheses indicate the number of independent slice experiments/number of animals per experimental group. P values were determined by one-way ANOVA followed by Sidak’s post hoc test.
