Line Plot from Scientific Research

Effects of clone 19, clone 2, Nivo_mIgG1, Nivo_D265A, and Nivo_Plus on T cell activation in a co-culture NFAT reporter system. Jurkat T cells expressing hPD-1 and a luciferase reporter driven by an NFAT response element (NFATrep) were cultured with TCS cells expressing an anti-CD3 (OKT3) scFv antibody construct. Signaling effects of PD-1 antibodies were measured in four settings: Jurkat PD-1 cells cultured with TCS cells expressing mFcγR2b. The dashed horizontal line in each plot indicates the level of luciferase production by resting Jurkat T cells.

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