Whole-brain FC change (Euclidean distance from baseline) for all rest scans across conditions. FC change for MTP, psilocybin and day-to-day are in comparison to same-participant baseline. White dots indicate median, vertical lines indicate quartiles. LME model predicting whole-brain FC change: ten psilocybin doses (275 observations), estimate (95% CI) = 15.83 (13.50, 18.15), t (266) = 13.39, P = 1.36 x 10 -31 , uncorrected. For the full FC distance matrix with session labels, see Extended Data Fig. 3 .
