Microscopy from Scientific Research

In situ hybridization (RNAscope) validation of depletion of RELN + excitatory neurons in the EC of individuals with AD relative to individuals without AD. Representative images (left) include Hoechst (blue), vGlut transcripts (green puncta) and RELN transcripts (magenta puncta). Scale bars, 20 m. Quantification (right) was performed using unpaired two-tailed Student’s t -tests ( P = 0.0242). Data are mean s.e.m. n = 5 (non-AD) and n = 4 (AD) individuals.

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