Densities of 6 mefloquine molecules (mesh, post-processed density map, 3). Inset: the planar mefloquine body is inserted into a hydrophobic groove between TM1 and TM2 of one Cx36 monomer and a portion of TM1 of the neighboring monomer; the head-group (head) orients towards the pore, making contacts with the polar region of the TM1 and with the neighboring mefloquine molecule.
