Five ‘atypical’ children, 70-0710-1, maintaining aviremia and mostly undetectable or not significantly different from undetectable total DNA loads despite persistent cART non-adherence by history and by analysis of plasma cART levels. Periods of loss to follow-up are shown as ‘ltfu’. Black arrows indicate timepoints at which LPV concentration was >500 ng ml −1 ; red arrows indicate timepoints at which LPV concentration was <500 ng ml −1 ; blue triangles indicate LPV concentration; red triangles indicate pVL copies per milliliter; solid black triangles indicate total HIV DNA load (cpm PBMCs) detected; open blank triangles indicate total HIV DNA load undetectable or not significantly different from undetectable; open circles indicate total HIV nucleic acid undetectable by GeneXpert; black asterisk indicates aviremia in association with prescribed cART that excluded LPV (that is, for 80-0114-1, AZT/3TC/NVP at 1 month of age); and red asterisks indicate cART non-adherent for the medications prescribed, but un-prescribed anti-retroviral drugs were detected at therapeutic levels at these timepoints, which could explain aviremia (see text for further specifics). conc, concentration; count/µl, count per microliter; m, months.
