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Maximum fluorescence (%CFB, mean s.e.m.) in CSF samples collected at baseline, week 21 and week 45 in patients treated with placebo ( n = 6), UB-312 300/100/100 g ( n = 6, one patient provided CSF only at baseline and is excluded) or UB-312 300/300/300 g ( n = 6, one individual who was Syn-SAA negative at baseline is excluded) showed a significant difference between placebo and 300/100/100 g (two-way ANOVA, time treatment interaction, P = 0.0343).
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