TDP-43 levels in plasma sEV of the Sant Pau cohort stratified by clinical diagnosis. The long horizontal line represents the median and the short horizontal lines represent the IQR. Kruskal Wallis test with Dunn’s correction for multiple comparisons. HC versus ALS P = 0.0000075, HC versus ALSFTD P = 0.0000046, ALS versus bvFTD P = 0.00074, HC versus PSP P = 0.578, ALS versus bvFTD P = 0.000009, ALS versus PSP P = 0.000007, ALSFTD versus bvFTD P = 0.0000043, ALSFTD versus PSP P = 0.0000055, bvFTD versus PSP P = 0.0005; * P < 0.05, ** P < 0.001, *** P < 0.0001, **** P < 0.00001. Biologically independent samples: HC n = 50, ALS n = 65, ALSFTD n = 58, bvFTD n = 50 (+23 mutations), PSP n = 41.
