Scatter Plot from Scientific Research

To establish the clinical validity of our biotypes, we evaluated the cluster-specific differences in reported symptoms. After establishing these differences in the full sample, we evaluated the stability of these symptom and behavioral profiles across two random half-splits of our data, deriving, each time, biotypes from the first half and assigning participants in the second half to a biotype derived from the first. We also followed the same procedure in a leave-study-out framework, leaving one of four of our studies out in each iteration.

DOI