Measures of task-based activation and functional connectivity and task-free connectivity derived from regions belonging to six circuits for which we have established relevance to depression and anxiety. (i) Default mode (D), salience (S) and attention (A) circuits were derived from the task-free periods of the fMRI. The Negative and Positive (P) circuits were engaged by a facial expressions task. In particular, the Negative circuit was engaged in Threat Conscious (NTC), Threat Non-conscious (NTN) and Sad (NS) conditions. The cognitive control circuit (C) was engaged by a Go-NoGo task. (ii) We defined the regions of interest comprising each circuit from the meta-analytic platform Neurosynth and refined them based on quality control, a set of psychometric criteria and whether they were implicated in depression and anxiety. (iii) We extracted functional connectivity between circuit regions for task-free circuits, and activation and connectivity of regions for task-engaged circuits (regions shown as sphere, connectivity shown as lines).
