Bubble Plot from Scientific Research

Top-ranked differentially expressed genes in ARID1B+/− SATB2+ ExNs, found in 5 out of 5 pairwise comparisons, ordered by descending fold-change (FC) (red, upregulated; blue, downregulated). Symbols mark previous associations with CC development or agenesis (ACC) (★) and intellectual disability (ID) or autism spectrum disorder (ASD) (⋅). Supporting literature: ID and/or ASD phenotypes have been associated mutations or encompassing microdeletions in IL1RAPL1, DPYD, PCLO, RUNX1T1, and NLGN1. Gene variants of ZNF804A are a risk factor for reduction in white matter in the CC, and FAM13A is a determinant of human brain asymmetry and handedness. Callosal agenesis or dysgenesis has been described in patients harboring mutations or microdeletions in EPHA7, NFIB, MID1(Opitz’ syndrome), PRKD1, and BCL11A/CTIP1(2p15-16.1 syndrome). See also Figures S3 and S4.

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