Chemical Structure from Scientific Research

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A comparison of LEI-800 (current study), CIP (PDB: 2XCT) and SD8 (PDB: 4CKL) binding sites on the GyrA DNA-binding surface. LEI-800 is shown as golden, SD8 as pink and CIP as grey stick representations. A quinoline ring of LEI-800 shares the binding pocket with the aminocoumarin moiety of SD8, but unlike SD8, LEI-800 does not interfere with DNA binding.
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