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Synthetic route to make conformationally restricted isoquinoline sulfonamide LEI-800. The synthesis consists of 12 individual steps, of which steps 2–4 introduce a second stereocentre. The synthetic procedures are found in full in Supporting Information. DMAP, dimethylaminopyridine; THF, tetrahydrofuran; ACN, acetonitrile; DCM, dichloromethane.

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