Time-dependent changes in PWMT after continuous 48-h SR (Day 0) and a week of lactate administration (Day 1, 2, 3, 5, 7, and 9) in mice (left) and those on the day of incision after SR (Day 0) and post-incision with lactate administration (Day 1, 3, 5, 7, and 9) (right). n =8 per group. SR + PBS vs. SR + NaLA: * p <0.05, ** p <0.01; SI + PBS vs. SI + NaLA: # p <0.05, ## p <0.01, ### p <0.001.