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The sensitivity of palbociclib and dalpiciclib in HNMM-PDC with CDK4 amplification (AMP) and without CDK4-amplified (wild type, WT). CDK4/6-RB signaling pathway and downstream proteins were detected by western blotting in the indicated groups. Scoring of Ki-67 and PRB staining are summarized as the mean SEM. Tumor volume, tumor weight, body weight, Ki67 expression, and pRB expression were analyzed with Student’s t test. ns, not significant

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