Mediation analysis of 18 LTL-affecting exposures ( y -axis; left) on lifespan ( y -axis; right) through LTL with effect size estimates and 95% confidence intervals (CI; x -axis) of the total effect (i.e., IVW MR estimate of exposure on outcome; purple), direct effect (i.e., not mediated by LTL; MVMR estimate; pink) and indirect effect (i.e., LTL mediation by product method; orange) as displayed in the scheme on top of the figure. Displayed are relationships with significant ( p < 0.05/323 = 1.5e-4 ) total and indirect effects.
