Line Plot from Scientific Research

Schematic representation of LTL shortening across different female reproductive life phases. Relation (beta) between predicted (i.e., regression model fit) standardized LTL (y-axis) and age (x-axis) across three female reproductive life periods (red). Dotted vertical lines indicate mean age at first live birth (26 years) and mean age at menopause (50 years). As a comparison, we depict the quadratic LTL regression in males (beta_age ; beta_age^2 ; blue). 95% confidence intervals are shown for the predictions. Yellow background indicates the age range for which data are available (40–70 years) and used to build predictions; regions outside this range are extrapolated for males and estimated from age at first live birth and age at menopause information for females. The x-axis was set to begin at age 18, reflecting the shift in the rate of LTL decline after puberty [ 30 ]. This change cannot be accurately captured by our linear models, which are based on LTL measurements at older ages

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