Network from Scientific Research

Network analysis to identify direct and indirect effects of FUS knockdown. FUS eCLIP data was used to identify direct targets of FUS. eCLIP datasets ( N ) or ePRINT peaks ( O ) were then used to identify targets of the RBPs showing a change in activity shown in Figs. 1 M and S6B. eCLIP captures 30/53 of the genes that are differentially expressed upon FUS knockdown (DEGs). ePRINT captures 38/53 DEGs. Colour legend on the left indicates expression changes for RBPs and genes. The flow chart on the right displays the strategy used to map the network.

DOI