Benchmark of sensitivity versus FDR. The upper row is simulated from a modified version of Rosette simulation to favor position-informed models. The bottom row is the results from standard Rosette . Circles, triangles, squares, and crosses represent LOF variant selection at adjusted p-values or lfsr of 0.001, 0.01, 0.05, and 0.10, respectively. Variants with the opposite sign of selection are then excluded. Ideally, for all methods besides Rosace , each symbol would lie directly above the corresponding symbol on the x-axis indicating true FDR. For Rosace , lfsr has no direct translation to FDR so the cutoff represented by the shape is theoretically on a different scale. (DiMSum can only process two time points, and thus is disadvantaged in experiments with more than two time points, or one selection round)
