Overview of HATCHet2. Starting from aligned DNA sequence reads from one or more bulk tumor samples from the same patient, HATCHet2 identifies integer-valued copy-number profiles for multiple tumor clones along with the proportion of each clone in every sample. Steps in orange boxes indicate key methodological improvements in HATCHet2 compared to HATCHet [ 30 ], with orange text highlighting the new features in each step
