Line Plot from Scientific Research

ABCA4 promoter interaction frequencies using UMI-4C in human neural retina and RPE/choroid from retinal donors (n = 3, interacting regions (IRs) indicated 1–12). Candidate cis -regulatory elements (cCREs) within IRs were identified using publicly available epigenomic data from human retina: ATAC-seq from bulk retina and scATAC-seq from photoreceptor cells; ChIP-seq for histone marks H3K27ac and H3K4me2, retinal transcription factors (TFs) (CRX, OTX2, and NRL) and the architectural protein CTCF. Epigenomic data for RPE/choroid included bulk ATAC-seq and ChIP-seq targeting H3K27ac and CTCF. All these data were integrated to finely map cCREs.

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