Scatter plot of the TMD interface in GPCRs. The y axis represents the TMD interface area per protomer, and the x axis is the number of residues from individual protomers in the TMD interface. The former is calculated using freeSASA, while the latter is counted once the residual interface area is over 1 A 2 . PDBs with multiple protomers are averaged in the plot. The circles are colored according to GPCR subfamilies and their diameters are proportional to the number of TMs in the interface.
