Sex-specific differences in the secretion of NETs and pro-inflammatory cytokines by peripheral neutrophils from active BU patients (female: n = 4; male: n = 4) and HCs (female: n = 4; male: n = 5). Data are shown as means SEM. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. # P < 0.05; ## P < 0.01; ### P < 0.001; P -values were calculated by the one-way ANOVA (Tukey’s multiple comparison test). In all instances, n refers to the number of each group.