Protein Structure from Scientific Research

Predicted binding poses and corresponding interactions of rucaparib (left) and M324 (right) on GSK3B kinase. As it can be observed, neither rucaparib nor M324 is able to mimic the interactions with the hinge region residues Asp133 and Val135 observe with the more potent GSK3B inhibitor co-crystalized, alsterpaullone. Corresponding chemical structures are provided with lactam highlighted in red. The carbons of key residues are colored orange.

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